The PRKAR2B Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PRKAR2B. This antibody recognizes Human, Mouse, and Rat antigen. The PRKAR2B Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subunit Structure: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2. Forms a complex composed of PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation and regulates GSK3B activity (PubMed:25920809).
Post-translational Modifications: Phosphorylated by the activated catalytic chain.
Similarity: Belongs to the cAMP-dependent kinase regulatory chain family